Crystal density

John Williams
(not verified)
Posted in: , on 9. Jan. 2006 - 19:07

Lynn,

I was hoping that you may be able to help me. I am doing a college design project and I'm responsible for designing a centrifuge in a pharmaceutical primary production process. I was hoping that you might be able to give me some indicationof the density of the active pharmaceutical ingredient crystal leaving the crystalliser and entering the centrifuge.

Thanks,

John

Crystal Density

Posted on 10. Jan. 2006 - 09:59

It is not clear whether your interest is in the solid density of the crystal or the density of the bulk material entering the centrifuge. The former is definitive and dependent on the nature of the basic material, whereas the bulk density of a particulate mass is variable according to the state of packing of the constituent particles. A crystaline slurry fed into a centrifuge will rapidly attain a compacted structure that expresses excess fluid. Residual saturation will percolate as accelerated drainage, with little change in the solids volume. The discharge of centrifuged cake causes significant voids to be made between agglomerated lumps of the cohesive bulk, but the density then depends on subsequent handling conditions.

I suspect that the answer to your query is that the slurry density depends on the degree of concentration, but it will not stay in this condition during the centrifuge loading cycle because the initial layer will bed down as entered. I would expect the important design feature to be the porosity of the bed under conditions of enhanced gravity, as the fluid contained in subsequent layers of additions have to penetrate an increasing bed depth.

Perhaps one with more direct experience with the operation of different types of centrifuges could provide a more detailed expanation.

RPD - Invista (UK) Ltd., U.K.
(not verified)

Re: Crystal Density

Posted on 10. Jan. 2006 - 10:26

John,

I assume you are looking for the true density to evaluate the density difference between solid and liquor for centrifuge performance.

The density will obviously be material dependent and the manufacturers of it may put that information of the material datasheets.

If you want make a guestimate, we handle a crystaline carboxylic acid and its true density is 1530 kg/cum.

Cheers